Yes! SMTPit Pro and MMEmail can send email through your Apple MobileMe account. This will not work with the classic SMTPit plug-in, as the connection requires SSL, which the classic plug-in does not support. The settings below will allow you to work with your MobileMe account.

Host: smtp.me.com
From Address: Your full email address
Authentication Type: Login
Username: Your MobileMe member name (without "@me.com" or "@mac.com")
Password: Your MobileMe password
Port: 587
TLS/SSL Type: AfterConnect